Minimising resistance should therefore be considered comprehensively, by resistance mechanism, microorganism, antimicrobial drug, host, and context; parallel to new drug discovery, broad ranging, multidisciplinary research is needed across these five levels, interlinked across the health-care, agriculture, and environment sectors. Seasonal variation in abundance of resistance genes was observed, with average concentrations of 3. Antibiotic resistance is a global health crisis linked to increased, and often unrestricted, antibiotic use in humans and animals. Reproduced with permission from ref Waste disposal practices differ from location to location, ranging from centralized collection and landfilling or incineration at one extreme to indiscriminate dumping at the other. Toward a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance. Nanosensors for water quality monitoring.